Psilocybe: The Mom of All Magic Mushrooms

Whereas psilocybe will not be truly the mom of all magic mushrooms, it’s the preferred genus of magic mushrooms, the mushrooms most related to a psychedelic excessive. Learn on to seek out out extra about these mushrooms, and what the heck is in them.

Psilocybe mushrooms are the preferred of the psychedelic mushrooms, however there’s nonetheless a lot we have to study these fungi! Cannadelics is an impartial information web site bringing you information and commentary within the rising cannabis and psychedelics areas. We additionally present the Cannadelics Weekly E-newsletter for our readers to entry common updates on huge tales. Test it out if you would like entry to offers on all types of cannabis and psychedelics merchandise. We’ve received vapes, smoking gadgets, edibles, different paraphernalia, and cannabinoids just like the ever-popular Delta 8 & HHC. Head to our ‘better of’ lists for extra info, and attempt to solely buy the merchandise you actually need to use.

An summary of psilocybe mushrooms

Once we hear the phrases ‘magic mushrooms’ or ‘psychedelic mushrooms’ the speedy affiliation is with ‘psilocybin mushrooms’. Fact is, there isn’t only one sort of psilocybin mushroom, and so they come from completely different genera. The preferred genus is the psilocybe grouping, although there are different genera, like Panaeolus and Conocybe.

Psilocybe mushrooms come from the Hymenogastraceae household of fungi, and had been cut up initially into two main teams, that weren’t properly related to one another. One group for hallucinogenic species, and one group for non-hallucinogenic mushrooms. This was up to date later with the hallucinogenic mushrooms staying underneath the Hymenogastraceae household identify, and the non-hallucinogenic mushrooms (largely) changing into often known as the Deconica genera, underneath the Strophariaceae household.

The identify Psilocybe comes from the Greek phrases for “naked” or “bare” (psilós), and “head” or “swelling” (kúbe), to create a which means of “bare-headed”. That is in reference to the free pores and skin over the cap, which is removable, and which seems to be like a bald head. The mushrooms look fairly commonplace for magic mushrooms, most likely as a result of they’re the preferred, and subsequently pictured most ceaselessly. They’re long-stemmed brown mushrooms, with a small, normally umbrella-looking cap. The spore-prints vary from a lilac-brown to a darkish purplish-brown.

Psilocybe semilanceata
Psilocybe semilanceata

These mushrooms come from the overall Mesoamerica space which has the widest selection. However they are often discovered in lots of components of the world, with many species discovered in additional temperate climate circumstances. This genus consists of species like: P. cubensis, P. subcubensis, P. cyanescens, P. Mexicana, P. Semilanceata, P. Aurescens, and P. Pelliculosa, however there are a whole lot of various species on the earth.

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Psilocybe mushrooms comprise three psychedelic compounds referred to as psilocybin, psilocin, and baeocystin. The primary two of those are sometimes talked about, whereas the third is much less well-known. Whereas not all species inside this genus comprise these compounds, the vast majority of them do.

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Psilocybin, psilocin, and baeocystin

In terms of these mushrooms, there are three psychedelic compounds to contemplate. The primary, psilocybin, is most well-known, and is even used to refer to those mushrooms as psilocybin mushrooms. The fascinating factor about psilocybin? It’s thought of a ‘prodrug’ which suggests a biologically inactive compound till it breaks down into a special compound within the physique. The compound it breaks down into, is psilocin, making this the extra fascinating of the 2.

Psilocin exists as properly in these mushrooms, however in smaller quantities. Although psilocybin itself is inactive, it’s normally the extra dominant compound, which means the vast majority of the psilocin that impacts us, is decarboxylated from psilocybin. It’s subsequently psilocin that exerts its energy on serotonin receptors, and it’s this compound liable for the psychedelic journey. Psilocybin has the chemical components: C12H17N2O4P, which converts to C12H16N2O (psilocin).

What about this third compound, baeocystin? A lot much less is understood about it, although it was first synthesized in 1959 by a gaggle together with Albert Hofmann, the identical man that introduced us LSD, and is called an analog of psilocybin. Creator Jochen Gartz, who wrote Magic Mushrooms Across the World, contends that in a research, baeocystin was discovered to be about as psychoactive as the identical quantity of psilocybin. Gartz additionally self-administered 4mg as a part of a research, saying it made for “a mild hallucinogenic expertise.”

One other compound can be talked about in psilocybe mushrooms, norbaeocystin, however although there isn’t any proof, this compound is regarded as non-psychedelic. Maybe that story will change sooner or later as extra analysis is completed.

Psilocybe psychedelic compounds
Psilocybe psychedelic compounds

What different analysis exists on baeocystin?

Baeocystin is fascinating as a result of for as a lot as we learn about psilocybin, we all know means much less about its cousin which seems in the identical locations. Whereas Gartz talked of a hallucinogenic expertise, a 2020 research Synthesis and Organic Analysis of Tryptamines Present in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin, turned up that no hallucinogenic results had been produced in a mouse mannequin that used a head-twitch response. Researchers discovered “baeocystin was indistinguishable from the management mice that got saline.”

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On this research it was concluded “…baeocystin alone would seemingly not induce hallucinogenic results in vivo“. That is most likely as a result of “…baeocystin alone would seemingly not induce 5-HT2A receptor-mediated psychoactive results in vivo.” Researchers imagine that is due to MAO motion. MAO molecules use oxygen atoms to take out amine teams from different molecules, breaking them down. Baeocystin’s metabolite norpsilocin, found in 2017, will get degraded sooner within the physique in comparison with psilocin by the MAO. Researchers hypothesized that baeocystin can also’t cross the blood mind barrier.

How does norpsilocin do on the 5-HT2A receptor websites which are related to serotonergic psychedelics? This metabolite compound (4-HO-NMT) confirmed to be a full agonist, with the next efficiency than psilocin – Emax 93% in comparison with psilocin’s 73%. Which suggests although baeocystin won’t be psychoactive, its metabolite norpsilocin does appear to be. That norpsilocin has these properties opens an entire new door of research into magic mushrooms, and their medicinal elements. Although it seems fairly potential that MAOs maintain the compound from getting an opportunity to exert its results.

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Say the researchers, “The in vivo information mixed with evaluation of the pharmacological liabilities recommend it’s unlikely that baeocystin or its putative metabolite norpsilocin contribute considerably to centrally mediated psychedelic results, seemingly as a result of speedy degradation by MAO or lack of ability to cross the blood−mind barrier.” However went on to say, “…baeocystin may probably exert a synergistic impact with psilocin/psilocybin by competing for MAO, successfully rising psilocin focus within the blood.”

The concept baeocystin itself doesn’t trigger a psychedelic response was reiterated by mycologist Paul Stamets, an professional on magic mushrooms, who additionally self-administered 10mg of the compound. He defined on the Joe Rogan present that he by no means received a excessive off the pure compound. In keeping with Stametz, “I used to be prepared for liftoff. I hoped for liftoff, I do know what liftoff appears like, and I didn’t get it.”

Sadly, whereas psilocybin is straightforward to get as a pure compound, entry to baeocystin and norpsilocin is seemingly a lot more durable, resulting in much less experiences and information on these compounds, aside from the examples talked about. It suffices to say, that there’s actually far more to know, and hopefully in upcoming years, extra will come out.

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Psilocybe cubensis
Psilocybe cubensis

Oregon and psilocybe mushrooms

Oregon was the very first state to legalize the leisure use of magic mushrooms on a state-wide foundation. In a 2020 poll measure the state handed the Psilocybin Mushroom Companies Program Initiative by way of Measure 109. 55.75% of the voting inhabitants voted sure to start out this adult-use magic mushroom market.

Nevertheless, Oregon is by no means making a free-for-all. Not solely is the state solely permitting authorized use inside specified services, and underneath the watch of a trip-sitter (although one with out medical/psychological coaching), it’s additionally solely permitting one kind of mushroom for this market. The one allowed species of psilocybe mushrooms known as Psilocybe cubensis, and is the preferred of the psilocybe mushrooms. This level was very a lot debated after draft guidelines got here out earlier, however Oregon didn’t budge on this level, reasoning:

“OPS acquired feedback requesting that the principles permit extra species of mushrooms and use of extra substrates. The Oregon Psilocybin Advisory Board beneficial limiting cultivation to Psilocybe cubensis and prohibiting substrates that will pose a threat to well being and security.”

And continued, “To keep away from the chance related to lethal, toxic look-alikes and the potential for wooden lover’s paralysis and animal-borne pathogens, OPS has upheld this advice in ultimate guidelines… OPS seems to be ahead to consideration of extra species sooner or later by continued dialog with the general public and proposals from the Oregon Psilocybin Advisory Board.”

Realistically, whereas the legalization is weak at finest, it’s the begin to one thing. Whether or not different states trying to do that will develop out past that one species, is but to be seen. Contemplating the variety of states trying into legalizations for entheogenic vegetation, it’s onerous to think about that legal guidelines gained’t get just a little looser over time.

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Psilocybe mushrooms characterize the most important genus of magic mushrooms, which comprises probably the most types of mushrooms with psychedelic compounds. Likelihood is, if you happen to’re doing magic mushrooms, you’re most probably doing a little species of psilocybe.

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